The importance of membrane voltage in uptake of bile salts into hepatocytes is not known. Electrogenicity of the primary bile salt transport process, Na-bile salt cotransport, has been difficult to determine because the large K and Cl conductances of the sinusoidal membrane (GK and GCl, respectively) obscure any transport associated currents.
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known.
After diffusion (bound by intracellular bile salt-binding proteins) to the canalicular membrane, monoanionic bile salts are secreted into bile canaliculi by the bile salt export pump Bsep (rodents) or BSEP (humans). The pre-S1 domain of the large HBsAg protein promotes attachment and entry of HBV into the hepatocyte via liver cell–specific receptor recently identified as Na (sodium) taurocholate cotransporting polypeptide (NTCP), which is an integral membrane protein used in bile acid transport. 23,24 There is evidence that hepatocyte entry may be a multistep process including binding to heparan sulfate proteoglycans, 25 which are found on a variety of cells, and clathrin-mediated endocytosis. 26 The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts.
NTCP/SLC10A1 (humans) and Ntcp/ Slc10a1 (rodents) are localized on the basolateral/sinusoidal domain of hepatocytes and their main function is the extraction of bile acids from portal blood, ultimately leading to their biliary 2003-04-01 Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer]. Na BS− Fig. 2. Bile salt carriers in rat and human hepatocytes, cholangiocytes, renal tubular cells and enterocytes. At the basolateral membrane, the Na+–taurocholate cotransporting polypeptides Ntcp (rat) and NTCP (human) mediate uptake of conjugated bile salts (BS−). In rat liver, Na+- 2002-01-01 The Bulletin, MDI Biological Laboratory V. 52, 2013 20 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Alison Pierik2 and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 2008-03-28 The Bulletin, MDI Biological Laboratory V. 53, 2014 4 Characterization of a bile salt transport system in isolated hepatocytes from adult sea lamprey (Petromyzon marinus) Shi-Ying Cai1, Daniël A. Lionarons1, and James L. Boyer1,2 1 Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 2 Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672 Although less is known about bile salt transport in the kidney, bile salts that escape first-pass clearance by the liver after reabsorption from the intestine are filtered at the glomerulus, where they are thought to be reabsorbed by a sodium-dependent bile salt transport mechanism in the proximal convoluted tubule.18–20 Thus, under nor-mal conditions, bile salt losses in urine are minimal. It has been proposed that the hepatocellular Na(+)-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes.
L.Maillette de Buy Wenniger, U. Beuers, in Encyclopedia of Biological Chemistry (Second Edition), 2013 Physiological Hepatocellular Bile Salt Transport. Bile salt uptake into the hepatocyte is predominantly mediated by the Na +-taurocholate-cotransporting polypeptide (NTCP), and, to a lesser extent, by the organic anion transporting protein (OATP) family.
NA = ej tillgängligt a. Medelvärde från flera experiment med samma (bile salt export pump), NTCP (sodium taurocholate cotransporter protein),.
Hepatocellular bile salt uptake is mediated predominantly by the Na + -taurocholate cotransport proteins Ntcp (rodents) and NTCP (humans) and by the Na + -independent organic anion-transporting polypeptides Oatp1, Oatp2, and Oatp4 (rodents) and OATP-C (humans). After diffusion (bound by intracellular bile salt–binding proteins) to the canalicular
It is strictly dependent on the extracellular presence of sodium. 2003-04-01 · Bile salt uptake via Ntcp/NTCP is unidirectional with a sodium-to-taurocholate stoichiometry of 2:1, i.e., cotransport of two Na + with one taurocholate molecule, and electrogenic, i.e., it is driven by both the transmembrane Na + gradient which in turn is maintained by a Na +-K +-ATPase and the intracellular electrical potential derived from the outward diffusions of K + (210, 245). We characterized expression and activity of the bile salt transporters Na(+)/taurocholate (TC) cotransporting polypeptide (Ntcp), and bile salt export pump (Bsep), and the expression of organic anion transporting polypeptides 1 and 2 (Oatp1 and 2) and multidrug resistance associated protein-2 (Mrp2) in pregnancy and throughout lactation in rats. These results suggest that the proteins involved in Na + /bile salt cotransport are similar in renal and ileal brush-border membranes, but differ from those in hepatocytes.
1 ways to abbreviate Na(+)-bile Salt Co-transporter. How to abbreviate Na(+)-bile Salt Co-transporter? Get the most popular abbreviation for Na(+)-bile Salt Co-transporter updated in 2021
1992-08-01
The Na+/bile salt co-transporter of the pig ileal brush border membrane has been expressed in Xenopus laevis oocytes. Injection of pig ileal poly (A)+ RNA into oocytes resulted in the functional expression of an Na(+)-gradient-stimulated taurocholate uptake within 2-5 days. The expressed Na(+)-dependent taurocholate uptake exhibited saturation kinetics (apparent Km
2021-04-01
bile acid moieties (GI and G2) are tethered together via a spacer, X, and where one of the two bile acid moieties carries a photoactivatable group.
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The enterohepatic circulation of bile acids promotes efficient recycling of bile acids with adequate small bowel concentrations maintained to Ökade renal utsöndring av salt och vatten c. The HCl cotransporter c.
Analysis of structure-activity data allows us to depict our hypothesis for the interaction of bile salt and Na with the membranal recognition site of this transport system. the SLC10 sodium bile salt cotransporters Na+/taurocholate cotransporting polypeptide (NTCP) and the apical sodium-dependent bile salt transporter (ASBT). While expression of NTCP is restricted to
The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species.
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The Na-K-Cl cotransporter is a protein that aids in the secondary active transport of sodium, potassium, and chloride into cells. In humans there are two isoforms of this membrane transport protein, NKCC1 and NKCC2, encoded by two different genes. Two isoforms of the NKCC1/Slc12a2 gene result from keeping or skipping exon 21 in the final gene product. NKCC1 is widely distributed throughout the human body; it has important functions in organs that secrete fluids. NKCC2 is found
NTCP/SLC10A1 (humans) and Ntcp/ Slc10a1 (rodents) are localized on the basolateral/sinusoidal domain of hepatocytes and their main function is the extraction of bile acids from portal blood, ultimately leading to their biliary 2003-04-01 Sigma-Aldrich offers abstracts and full-text articles by [Michael Trauner, James L Boyer]. Na BS− Fig. 2. Bile salt carriers in rat and human hepatocytes, cholangiocytes, renal tubular cells and enterocytes. At the basolateral membrane, the Na+–taurocholate cotransporting polypeptides Ntcp (rat) and NTCP (human) mediate uptake of conjugated bile salts (BS−).
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1991-12-01
Kolhydrater Efter detta kan de transporteras in i cellen via Co-transport med H+.Cellens Julvi Hus i Göteborg AB. 031497575. Ingela Gathenhielms Gata 5.